Recombinant human FADD protein

FADD (Fas-associated protein with death domain) is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. This protein is implicated in survival/proliferation and cell cycle progression. FADD functions are also regulated via cellular sublocalization, protein phosphorylation, and inhibitory molecules. Recombinant FADD protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Fas-associated via death domain, GIG3, MORT1, Fas-associated via death domain, Fas-associated death domain FADD protein, Fas associated via death domain, Fas (TNFRSF6) associated via death domain, Fas associating death domain containing protein, Fas associating protein with death domain, Fas TNFRSF6 associated via death domain, Fas associating protein, GIG 3, MGC8528, Growth inhibiting gene 3 protein, MORT 1, H sapiens mRNA for mediator of receptor induced toxicity, Mediator of receptor induced toxicity

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

27.4 kDa (244aa) confirmed by MALDI-TOF

Additionnal Information

FADD, Fas-associated via death domain, GIG3, MORT1, Fas-associated via death domain, Fas-associated death domain FADD protein, Fas associated via death domain, Fas (TNFRSF6) associated via death domain, Fas associating death domain containing protein, Fas associating protein with death domain, Fas TNFRSF6 associated via death domain, Fas associating protein, GIG 3, MGC8528, Growth inhibiting gene 3 protein, MORT 1, H sapiens mRNA for mediator of receptor induced toxicity, Mediator of receptor induced toxicity, ATGP0407-10 µg, ATGP0407-20 µg, ATGP0407-50 µg, ATGP0407-100 µg, ATGP0407-250 µg, ATGP0407-500 µg, ATGP0407-1 mg, ATGP0407-10, ATGP0407-20, ATGP0407-50, ATGP0407-100, ATGP0407-250, ATGP0407-500, ATGP0407-1

References & Citations

Eberstadt M., et al. (1998) Nature. 392 (6679) :941-5. ; ; Matsuyoshi S., et al. (2006) Br J Cancer. 94 (4) :532-9.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_003815.1

Uniprot Accession Number

Q13158

Species

Human

AA Sequence

MDPF LVLLHSVSSS LSSSELTELK FLCLGRVGKR KLERVQSGLD LFSMLLEQND LEPGHTELLR ELLASLRRHD LLRRVDDFEA GAAAGAAPGE EDLCAAFNVI CDNVGKDWRR LARQLKVSDT KIDSIEDRYP RNLTERVRES LRIWKNTEKE NATVAHLVGA LRSCQMNLVA DLVQEVQQAR DLQNRSGAMS PMSWNSDAST SEAS