Recombinant human Annexin A5/ANXA5 protein

Annexin A5, also known as Annexin V, belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin A5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Recombinant Annexin A5 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Vascular anticoagulant-alpha, VAC-alpha, Thromboplastin inhibitor, PP4, Placental anticoagulant protein I, PAP I, Lipocortin V, ENX2, Endonexin II, CPB-I, Calphobindin I, ANX5, ANX A5, Annexin V, Annexin A5, Annexin 5, Anchorin CII

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

35.9 kDa (320aa) confirmed by MALDI-TOF

Additionnal Information

Annexin V, Annexin V, ANX5, ENX2, PP4, Anchorin CII, Annexin 5, Annexin A5, ANX A5, Calphobindin I, Endonexin II, Lipocortin V, PAP I, Placental anticoagulant protein I., ATGP0406-10 µg, ATGP0406-20 µg, ATGP0406-50 µg, ATGP0406-100 µg, ATGP0406-250 µg, ATGP0406-500 µg, ATGP0406-1 mg, ATGP0406-10, ATGP0406-20, ATGP0406-50, ATGP0406-100, ATGP0406-250, ATGP0406-500, ATGP0406-1

References & Citations

Frey B., et al. (2009) J Immunotoxicol. 6 (4) :209-16. ; ; Steele AJ., et al. (2009) Blood. 114 (6) :1217-25.;

Other References

Shen MY et al., [Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles. (Diabetes Metab Syndr Obes. 2021) {https://pubmed.ncbi.nlm.nih.gov/34079312/}; ; Sakamoto N et al., Anti-annexin A4 antibody as a biomarker for desquamative interstitial pneumonia. (J Autoimmun. 2025) {https://pubmed.ncbi.nlm.nih.gov/40156961/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_001145.1

Uniprot Accession Number

P08758

Species

Human

AA Sequence

MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI KGDTSGDYKK ALLLLCGEDD