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Recombinant human HDGF protein

Hepatoma-derived growth factor isoform a, also known as HDGF, belongs to the hepatoma-derived growth factor family. HDGF was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. This nuclear targeted vascular smooth muscle cell mitogen is a heparin-binding protein that is highly expressed in tumor cells where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. Recombinant human HDGF was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Hepatoma-derived growth factor isoform a, HMG1L2, Hepatoma-derived growth factor isoform a Hepatoma derived growth factor, High mobility group protein 1 like 2

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

11.5 kDa (100aa) confirmed by MALDI-TOF

Additionnal Information

HDGF, Hepatoma-derived growth factor isoform a, HMG1L2, Hepatoma-derived growth factor isoform a Hepatoma derived growth factor, High mobility group protein 1 like 2, ATGP0402-10 µg, ATGP0402-20 µg, ATGP0402-50 µg, ATGP0402-100 µg, ATGP0402-250 µg, ATGP0402-500 µg, ATGP0402-1 mg, ATGP0402-10, ATGP0402-20, ATGP0402-50, ATGP0402-100, ATGP0402-250, ATGP0402-500, ATGP0402-1

References & Citations

Everett AD., et al. (2003) Curr Drug Tarqets. 4 (5) :367-71. ; ; Everett AD., et al. (2004) Am J Physiol Lung Cell Mol Physiol. 28 (6) :L1194-201.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 10% glycerol, 1mM EDTA

Scientific Category

Growth factors

NCBI Accession Number

NP_004485

Uniprot Accession Number

P51858

Species

Human

AA Sequence

MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY

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