Recombinant human CDO1 protein
Cysteine dioxygenase (CDO1) is a mammalian non-heme iron enzyme that initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. This protein catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen. CDO1 is critical regulator of cellular cysteine concentrations and has an important role in maintaining the hepatic concentration of intracellular free cysteine within a proper narrow range. Recombinant CDO1 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CDO, CDO 1, CDO I, Cysteine dioxygenase type 1, Cytosolic cysteine dioxygenase
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.9 kDa (207aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sakakibara S., et al. (1976) Biochim Biophys Acta. 422 (2) :273-9. ; ; Ramsden DB., et al. (1997) Mol Pathol. 50 (5) :269-71.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Scientific Category
Redox Proteins
NCBI Accession Number
AAH_24241
Uniprot Accession Number
Q16878
Species
Human
AA Sequence
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