Recombinant human TCL1A protein
TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism. Recombinant TCL1A protein was expressed in E. coli and purified by using conventional chromatography techniques
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
13.4 kDa (114aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Herling M., et al. (2006) Leukemia. 20 (2) :280-5.; ; Hoyer KK., et al. (2005) J Immunol. 175 (2) :864-73.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001092195.1
Uniprot Accession Number
P56279
Species
Human
AA Sequence
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
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