Recombinant human NDRG1 protein
N-myc downstream regulated gene (NDRG) -1 is one of 4 members of the NDRG alpha/beta-hydrolase family. This protein is classified in databases as a tumor suppressor and heavy metal-response protein. Its functions include cell-cycle regulation, cellular differentiation, apoptosis, hypoxia response and metal-ion sensing. Mutation in the NDRG1 gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom (HMSNL), a severe autosomal recessive form of Charcot-Marie-Tooth (CMT) disease. Recombinant human NDRG1, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
43.9 kDa (402aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Richardson DR., et al. (2008) Biochim Biophys Acta. 1783 (10) :1981-92.; ; Costa M., et al. (2008) Carcinogenesis. 29 (1) :2-8.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1mM PMSF, 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_006087
Uniprot Accession Number
Q92597
Species
Human
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