Recombinant human CCL26/Eotaxin-3 protein

CCL26 is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC) . This protein is involved in immunoregulatory and inflammatory processes. It is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26 was expressed in E. coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Product Specifications

Product Name Alternative

C-C motif chemokine ligand 26, CC chemokine IMAC, Eotaxin-3, Macrophage inflammatory protein 4-alpha, MIP-4-alpha, MIP-4a, Small-inducible cytokine A26, SCYA26, Thymic stroma chemokine-1, TSC-1, Chemokine N1

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

8.5 kDa (72aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

CCL26, Eotaxin3, Chemokine (C-C motif) ligand 26, Eotaxin-3, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1, Chemokine (C-C motif) ligand 26 CCL 26, CCL26, Chemokine (C C motif) ligand 26, macrophage inflammatory protein 4-alpha, MIP 4a, MIP 4alpha, MIP4a, MIP4alpha, SCYA 26, Small inducible cytokine A26, Small inducible cytokine subfamily A (Cys Cys) member 26, Small inducible cytokine subfamily A member 26, Thymic stroma chemokine 1, TSC 1, TSC1, ATGP0378-10 µg, ATGP0378-20 µg, ATGP0378-50 µg, ATGP0378-100 µg, ATGP0378-250 µg, ATGP0378-500 µg, ATGP0378-1 mg, ATGP0378-10, ATGP0378-20, ATGP0378-50, ATGP0378-100, ATGP0378-250, ATGP0378-500, ATGP0378-1

References & Citations

Imai T., et al. (1996) J Biol Chem. 271 (35) : 21514-21.; ; Kakinuma T, . et al. (2002) Cytokine. 20 (1) :1-6.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_006063

Uniprot Accession Number

Q9Y258

Species

Human

AA Sequence

MTRGSDISKT CCFQYSHKPL PWTWVRSYEF TSNSCSQRAV IFTTKRGKKV CTHPRKKWVQ KYISLLKTPK QL

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