Recombinant human Profilin 1/PFN1 protein
Profilin1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. This protein significantly enhances skin wound healing in-vitro and in-vivo that may be mediated by purinergic receptors. It is also active in endothelial cell migration and vessel sprouting. It is thought to regulate actin polymerization in response to extracellular signals. Recombinant Profilin1 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Profilin-1, Profilin I, Profilin, Pfn1, Actin binding protein
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
15 kDa (140aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kwiatkowski DJ, et al. (1988) J. Biol. Chem. 263 (12) : 5910-5; ; Harbeck B., et al. (2000) J. Biol. Chem. 275 (40) : 30817-25.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_005013
Uniprot Accession Number
P07737
Species
Human
AA Sequence
Frequently Asked Questions
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