Recombinant human CCL5/RANTES protein
Rantes, also known as CCL5, is the protein classified as a chemotactic cytokine or chemokine. This protein is a chemotactic for blood monocytes, memory T helper cells, eosinophils and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. Rantes also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also an HIV-suppressive factor released from CD8+ T cells. Recombinant RANTES protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
7.9 kDa (69aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Maghazachi Aa., et al. (1996) Eur J Immunol. 26 (2) :315-9. ; ; Duggal P., et al. (2005) J Acguir Immune Defic Syndr. 38 (5) :584-9.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_002976
Uniprot Accession Number
P13501
Species
Human
AA Sequence
MSPYSSDTTP CCFAYIARPL PRAHIKEYFY TSGKCSNPAV VFVTRKNRQV CANPEKKWVR EYINSLEMS
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