Recombinant human CHMP2A protein
CHMP2A, also known as chromatin modifying protein 2A, belongs to the SNF7 family and it is component of the ESCRT III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. Recombinant CHMP2A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.2 kDa (242aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Lata S., et al. (2008) Science. 321 (5894) :1354-7. ; ; Agromayor M., et al. (2006) J Biol Chem. 281 (32) :23083-91.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 30% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_055268.1
Uniprot Accession Number
O43633
Species
Human
AA Sequence
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