Recombinant human Neurokinin B protein
Neurokinin B, a member of the substance P-related tachykinin family, was previously known to be present in the same hypothalamic neurons as kisspeptin. This protein and its receptor are critical switches of regulator of human puberty, governed by the brain through the release of the hormone GnRH (gonadotropin-releasing hormone) which starts a series of processes that ultimately leads to the production of sex hormones. Many studies suggest new approaches to the pharmacological control of human reproduction and sex hormone-related diseases. Recombinant human Neurokinin B, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
13.8 kDa (125aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Topaloglu AK., et al. (2009) . Nat Genet. 41 (3) :354-8; ; Rance NE., et al. (2009) . Peptides. 30 (1) :111-22.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_037383
Uniprot Accession Number
Q9UHF0
Species
Human
AA Sequence
QSFGAVCKE PQEEVVPGGG RSKRDPDLYQ LLQRLFKSHS SLEGLLKALS QASTDPKEST SPEKRDMHDF FVGLMGKRSV QPDSPTDVNQ ENVPSFGILK YPPRAE
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