Recombinant human Carbonyl reductase 3/CBR3 protein
Carbonyl reductase 3 (CBR3) is one of several monomeric NADPH-dependent oxidoreductases. This protein catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. It also contains three exons spanning 11. 2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. Some studies suggest that it mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy. Recombinant human CBR3, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
33 kDa (297aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Ohkura-Hada S., et al. (2008) . Open Dent J. 2:78-88.; ; Miura T., et al. (2009) . Life Sci. 85 (7-8) :303-8.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Redox Proteins
NCBI Accession Number
NP_001227
Uniprot Accession Number
O75828
Species
Human
AA Sequence
Frequently Asked Questions
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