What is the catalog number for Recombinant human Ataxin-3 protein?

The catalog number for Recombinant human Ataxin-3 protein is ATGP0344-250.

What sizes are available for Recombinant human Ataxin-3 protein?

Recombinant human Ataxin-3 protein is available in the following size(s): 250 µg.

Is Recombinant human Ataxin-3 protein in stock?

Recombinant human Ataxin-3 protein is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant human Ataxin-3 protein

Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado-Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB) -binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Ataxin 3, ATX3, MJD, MJD1, SCA3, JOS, ATXN3, AT3, EC 3.4.22., Josephin, Machado Joseph disease, Machado Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD gene, Rsca3, SCA3 gene, Spinocerebellar ataxia type 3 protein

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

42.4 kDa (370aa) confirmed by MALDI-TOF

Additionnal Information

Ataxin3, Ataxin 3, ATX3, MJD, MJD1, SCA3, ATXN3, JOS, ATXN3, AT3, EC 3.4.22., Josephin, Machado Joseph disease, Machado Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD gene, Rsca3, SCA3 gene, Spinocerebellar ataxia type 3 protein, ATGP0344-10 µg, ATGP0344-20 µg, ATGP0344-50 µg, ATGP0344-100 µg, ATGP0344-250 µg, ATGP0344-500 µg, ATGP0344-1 mg, ATGP0344-10, ATGP0344-20, ATGP0344-50, ATGP0344-100, ATGP0344-250, ATGP0344-500, ATGP0344-1

References & Citations

Doss Pepe EW., et al. (2003) . Mol Cell Biol. 23 (18) :6469-83. ; ; Paulson., et al. (1997) . Ann Neurol. 41 (4) :453-62.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 50 mM NaCl, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

AAH33711

Uniprot Accession Number

P54252

Species

Human

AA Sequence

MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ QQQQQQQQQQ QQQQGDLSGQ SSHPCERPAT SSGALGSDLG DAMSEEDMLQ AAVTMSLETV RNDLKTEGKK