Recombinant human Harmonin/USH1C protein
Harmonin, product encoded by uSH1c gene, is a scaffold protein that functions in the assembly of usher protein complexes. usher syndrome type I caused by mutations in uSH1C is an autosomal recessive sensory defect involving congenital profound sensorineural deafness, vestibular dysfunction, and blindness due to progressive retinitis pigmentosa. Hormonin has the ability to bind to many other proteins in cell membranes and coordinates their activities. Recombinant human Harmonin protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
64.6 kDa (570aa)
Additionnal Information
References & Citations
Siemens J., et al. (2002) . Proc Natl Acad Sci u S A. 99 (23) :14946-51.; ; Ouyang XM., et al. (2002) . Hum Genet. 111 (1) :26-30.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
AAH16057
Uniprot Accession Number
Q9Y6N9
Species
Human
AA Sequence
Frequently Asked Questions
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