Recombinant human BMP-3b/GDF-10 protein
GDF10 (Growth differentiation factor 10) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It is expressed in femur, brain, lung, skeletal, muscle, pancreas and testis, and it plays a role in head formation and may have multiple roles in skeletal morphogenesis. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Recombinant GDF10 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Growth differentiation factor 10, GDF-10, Bone morphogenetic protein 3b [Precursor], Bone inducing protein, BMP-3b, BIP
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
12.5 kDa (111aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Cunningham NS., et al. (1995) Growth Factors. 12 (2) :99-109.; ; Ducy P., et al. (2000) Kidney Int. 57 (6) :2207-14.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 0.1M NaCl, 1mM DTT, 40% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_004953.1
Uniprot Accession Number
P55107
Species
Human
AA Sequence
MQWDEPRVCS RRYLKVDFAD IGWNEWIISP KSFDAYYCAG ACEFPMPKIV RPSNHATIQS IVRAVGIIPG IPEPCCVPDK MNSLGVLFLD ENRNVVLKVY PNMSVDTCAC R
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