Recombinant human HOMER1 protein

Homer 1 (Homer protein homolog 1) belongs to Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The Homer 1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs) . Recombinant Homer 1 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

HOMER, Homer protein homolog 1, HOMER1, HOMER1A, HOMER1B, HOMER1C, Neuronal immediate early gene, SYN47, Ves 1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

44.5 kDa (391aa) confirmed by MALDI-TOF

Additionnal Information

HOMER, HOMER 1, HOMER 1A, HOMER 1B, HOMER 1C, Homer protein homolog 1, Homer protein homolog1, HOMER1, HOMER1A, HOMER1B, HOMER1C, Neuronal immediate early gene, Neuronal immediate early gene 1, SYN 47, SYN47, Ves 1, Ves1, ATGP0313-10 µg, ATGP0313-20 µg, ATGP0313-50 µg, ATGP0313-100 µg, ATGP0313-250 µg, ATGP0313-500 µg, ATGP0313-1 mg, ATGP0313-010, ATGP0313-020, ATGP0313-050, ATGP0313-100, ATGP0313-250, ATGP0313-500, ATGP0313-01M

References & Citations

Szumlinski KK., et al. (2008) Biochem Pharmacol. 75 (1) :112-133.; ; Roche KW., et al. (1999) J Biol Chem. 274 (36) :25953-7.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% glycerol, and 1mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_004263

Uniprot Accession Number

Q86YM7

Species

Human

AA Sequence

HMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITP NMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELATLKGN NAKLTAALLE STANVKQWKQ QLAAYQEEAE RLHKRVTELE CVSSQANAVH THKTELNQTI QELEETLKLK EEEIERLKQE IDNARELQEQ RDSLTQKLQE VEIRNKDLEG QLSDLEQRLE KSQNEQEAFR NNLKTLLEIL DGKIFELTEL RDNLAKLLEC S