Recombinant human PINX1 protein
PINX1 (PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. This protein contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. Recombinant human PINX1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
39.1 kDa (348aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Zhou XZ., et al. (2001) . Cell. 107 (3) :347-59; ; Yoo JE., et al. (2009) . J Mol Biol. 388 (5) :928-40;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing, 1mM DTT, 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_060354
Uniprot Accession Number
Q96BK5
Species
Human
AA Sequence
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Lentiviral human CDK1 shRNA (UAS) - Lentiviral human CDK1 shRNA (UAS, iRFP) plasmid
Samd9l sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
