Recombinant human PINX1 protein

PINX1 (PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. This protein contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. Recombinant human PINX1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

PIN2-interacting protein 1, PIN2-interacting protein 1, TRF1-interacting protein 1, Liver-related putative tumor suppressor, Protein 67-11-3, LPTL, LPTS, PINX1, PIN2-interacting protein 1 67-11-3 protein PIN2 interacting protein 1, Hepatocellular carcinoma-related putative tumor suppressor

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

39.1 kDa (348aa) confirmed by MALDI-TOF

Additionnal Information

PINX1, PIN2-interacting protein 1, PIN2-interacting protein 1, TRF1-interacting protein 1, Liver-related putative tumor suppressor, Protein 67-11-3, LPTL, LPTS, PINX1, PIN2-interacting protein 1 67-11-3 protein PIN2 interacting protein 1, Hepatocellular carcinoma-related putative tumor suppressor, ATGP0310-10 µg, ATGP0310-20 µg, ATGP0310-50 µg, ATGP0310-100 µg, ATGP0310-250 µg, ATGP0310-500 µg, ATGP0310-1 mg, ATGP0310-10, ATGP0310-20, ATGP0310-50, ATGP0310-100, ATGP0310-250, ATGP0310-500, ATGP0310-1

References & Citations

Zhou XZ., et al. (2001) . Cell. 107 (3) :347-59; ; Yoo JE., et al. (2009) . J Mol Biol. 388 (5) :928-40;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing, 1mM DTT, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_060354

Uniprot Accession Number

Q96BK5

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK