Recombinant human eIF-5A1/EIF5A protein
Eukaryotic translation initiation factor 5A (eIF5A) is the only protein Known to contain unusual amino acid formed by the action of deoxyhypusine synthase and deoxyhypusine hydroxylase using spermidine as the substrate. This protein was previously reported to be involved in the first step of peptide bond formation in translation; however more recent work implicates it as a universally conserved translation elongation factor. Modulation of eIF5A has been linked to proliferation and cancer. Recombinant human eIF5A protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
16.8 kDa (154aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Saini P, et al. (2009) . Nature. 459 (7243) :118-21; ; Gosslau A., et al. (2009) . J Cell Physiol. 219 (2) :485-93;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 50 mM Tris-HCl buffer (pH 7.5) containing 10 % glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_001961
Uniprot Accession Number
P63241
Species
Human
AA Sequence
Frequently Asked Questions
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