SSX4 cDNA

The product of SSX4 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. SSX4 may function as transcriptional repressors. SSX4 are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t (X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for SSX4.