GUK1 cDNA

GuK1, also known as GMK, belongs to the guanylate kinase family. This protein exists as a monomer that catalyzes the ATP-dependent conversion of GMP to GDP, thereby playing an essential role in the recycling of GMP. Via its catalytic activity, GuK1 is thought to participate in regulating the supply of guanine nucleotides to signal transduction pathways. Overexpression of GuK1 is associated with pituitary adenocarcinomas, suggesting that GuK1 is involved in tumorigenesis.

Product Specifications

Product Name Alternative

Guanylate kinase, GMK, GMP kinase, GMPK

Chromosomal Location

1q32-q41

Antigen Species

Human

Vector Type

PATGen (puc19-derived cloning vector)

Sequence

ATGTCGGGCC CCAGGCCTGT GGTGCTGAGC GGGCCTTCGG GAGCTGGGAA GAGCACCCTG CTGAAGAGGC TGCTCCAGGA GCACAGCGGC ATCTTTGGCT TCAGCGTGTC CCATACCACG AGGAACCCGA GGCCCGGCGA GGAGAACGGC AAAGATTACT ACTTTGTAAC CAGGGAGGTG ATGCAGCGTG ACATAGCAGC CGGCGACTTC ATCGAGCATG CCGAGTTCTC GGGGAACCTG TATGGCACGA GCAAGGTGGC GGTGCAGGCC GTGCAGGCCA TGAACCGCAT CTGTGTGCTG GACGTGGACC TGCAGGGTGT GCGGAACATC AAGGCCACCG ATCTGCGGCC CATCTACATC TCTGTGCAGC CGCCTTCACT GCACGTGCTG GAGCAGCGGC TGCGGCAGCG CAACACTGAA ACCGAGGAGA GCCTGGTGAA GCGGCTGGCT GCTGCCCAGG CCGACATGGA GAGCAGCAAG GAGCCCGGCC TGTTTGATGT GGTCATCATT AACGACAGCC TGGACCAGGC CTACGCAGAG CTGAAGGAGG CGCTCTCTGA GGAAATCAAG AAAGCTCAAA GGACCGGCGC CTGA

Additionnal Information

GUK-1, GUK1, GUK 1, Guanylate Kinase, GMPK, GMP kinase, GMK, ATGD0065-10 µg, ATGD0065-20 µg, ATGD0065-50 µg, ATGD0065-100 µg, ATGD0065-250 µg, ATGD0065-500 µg, ATGD0065-1 mg, ATGD0065-010, ATGD0065-020, ATGD0065-050, ATGD0065-100, ATGD0065-250, ATGD0065-500, ATGD0065-01M

Storage Conditions

Store the plasmid at -20C.

Formulation

Lyophilized

Scientific Category

Cancer

Omim

139270

NCBI Accession Number

NP_000849.1

Species

Human

Preparation

1. Centrifuge at 7000rpm for 1 minute.; ;2. Carefully open the vial and add 100 µL of sterile water to dissolve the DNA.; ; Each tube contains approximately 10 µg of lyophilized plasmid.

RNA Reference

NM_000858.5

DNA Size

594bp

Vector Description

This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.