BCL10 cDNA

BCL10, also known as B-cell lymphoma/leukemia 10, contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. It is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Product Specifications

Product Name Alternative

B cell CLL/lymphoma 10, BCL10, Immune signaling adaptor, CARMEN, CIPER, mE10, c-E10, CLAP

Chromosomal Location

1p22

Antigen Species

Human

Vector Type

PATGen (puc19-derived cloning vector)

Sequence

ATGGAGCCCA CCGCACCGTC CCTCACCGAG GAGGACCTCA CTGAAGTGAA GAAGGACGCC TTAGAAAATT TACGTGTATA CCTGTGTGAG AAAATCATAG CTGAGAGACA TTTTGATCAT CTACGTGCAA AAAAAATACT CAGTAGAGAA GACACTGAAG AAATTTCTTG TCGAACATCA AGTAGAAAAA GGGCTGGAAA ATTGTTAGAC TACTTACAGG AAAACCCAAA AGGTCTGGAC ACCCTTGTTG AATCTATTCG GCGAGAAAAA ACACAGAACT TCCTGATACA GAAGATTACA GATGAAGTGC TGAAACTTAG AAATATAAAA CTAGAACATC TGAAAGGACT AAAATGTAGC AGTTGTGAAC CTTTTCCAGA TGGAGCCACG AACAACCTCT CCAGATCAAA TTCAGATGAG AGTAATTTCT CTGAAAAACT GAGGGCATCC ACTGTCATGT ACCATCCAGA AGGAGAATCC AGCACGACGC CCTTTTTTTC TACTAATTCT TCTCTGAATT TGCCTGTTCT AGAAGTAGGC AGAACTGAAA ATACCATCTT CTCTTCAACT ACACTTCCCA GACCTGGGGA CCCAGGGGCT CCTCCTTTGC CACCAGATCT ACAGTTAGAA GAAGAAGGAA CTTGTGCAAA CTCTAGTGAG ATGTTTCTTC CCTTAAGATC ACGTACTGTT TCACGACAAT GA

Additionnal Information

, B cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, BCL10, CARMEN, c-E10, CIPER, CLAP, IMD37, Immune signaling adaptor, mE10, B cell lymphoma/leukemia 10, c E10, Ce10, ATGD0046-10 µg, ATGD0046-20 µg, ATGD0046-50 µg, ATGD0046-100 µg, ATGD0046-250 µg, ATGD0046-500 µg, ATGD0046-1 mg, ATGD0046-010, ATGD0046-020, ATGD0046-050, ATGD0046-100, ATGD0046-250, ATGD0046-500, ATGD0046-01M

Storage Conditions

Store the plasmid at -20C.

Formulation

Lyophilized

Scientific Category

Signal Transduction

Omim

603517

NCBI Accession Number

NP_003912.1

Species

Human

Preparation

1. Centrifuge at 7000rpm for 1 minute.; ;2. Carefully open the vial and add 100 µL of sterile water to dissolve the DNA.; ; Each tube contains approximately 10 µg of lyophilized plasmid.

RNA Reference

NM_003921.4

DNA Size

702bp

Vector Description

This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.