TAB1 cDNA

TAB1 encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Product Specifications

Product Name Alternative

3'-Tab1, MAP3K7IP1

Chromosomal Location

22q13.1

Antigen Species

Human

Vector Type

PATGen (puc19-derived cloning vector)

Sequence

ATGGCGGCGC AGAGGAGGAG CTTGCTGCAG AGTGAGCAGC AGCCAAGCTG GACAGATGAC CTGCCTCTCT GCCACCTCTC TGGGGTTGGC TCAGCCTCCA ACCGCAGCTA CTCTGCTGAT GGCAAGGGCA CTGAGAGCCA CCCGCCAGAG GACAGCTGGC TCAAGTTCAG GAGTGAGAAC AACTGCTTCC TGTATGGGGT CTTCAACGGC TATGATGGCA ACCGAGTGAC CAACTTCGTG GCCCAGCGGC TGTCCGCAGA GCTCCTGCTG GGCCAGCTGA ATGCCGAGCA CGCCGAGGCC GATGTGCGGC GTGTGCTGCT GCAGGCCTTC GATGTGGTGG AGAGGAGCTT CCTGGAGTCC ATTGACGACG CCTTGGCTGA GAAGGCAAGC CTCCAGTCGC AATTGCCAGA GGGAGTCCCT CAGCACCAGC TGCCTCCTCA GTATCAGAAG ATCCTTGAGA GACTCAAGAC GTTAGAGAGG GAAATTTCGG GAGGGGCCAT GGCCGTTGTG GCGGTCCTTC TCAACAACAA GCTCTACGTC GCCAATGTCG GTACAAACCG TGCACTTTTA TGCAAATCGA CAGTGGATGG GTTGCAGGTG ACACAGCTGA ACGTGGACCA CACCACAGAG AACGAGGATG AGCTCTTCCG TCTTTCGCAG CTGGGCTTGG ATGCTGGAAA GATCAAGCAG GTGGGGATCA TCTGTGGGCA GGAGAGCACC CGGCGGATCG GGGATTACAA GGTTAAATAT GGCTACACGG ACATTGACCT TCTCAGCGCT GCCAAGTCCA AACCAATCAT CGCAGAGCCA GAAATCCATG GGGCACAGCC GCTGGATGGG GTGACGGGCT TCTTGGTGCT GATGTCGGAG GGGTTGTACA AGGCCCTAGA GGCAGCCCAT GGGCCTGGGC AGGCCAACCA GGAGATTGCT GCGATGATTG ACACTGAGTT TGCCAAGCAG ACCTCCCTGG ACGCAGTGGC CCAGGCCGTC GTGGACCGGG TGAAGCGCAT CCACAGCGAC ACCTTCGCCA GTGGTGGGGA GCGTGCCAGG TTCTGCCCCC GGCACGAGGA CATGACCCTG CTAGTGAGGA ACTTTGGCTA CCCGCTGGGC GAAATGAGCC AGCCCACACC GAGCCCAGCC CCAGCTGCAG GAGGACGAGT GTACCCTGTG TCTGTGCCAT ACTCCAGCGC CCAGAGCACC AGCAAGACCA GCGTGACCCT CTCCCTTGTC ATGCCCTCCC AGGGCCAGAT GGTCAACGGG GCTCACAGTG CTTCCACCCT GGACGAAGCC ACCCCCACCC TCACCAACCA AAGCCCGACC TTAACCCTGC AGTCCACCAA CACGCACACG CAGAGCAGCA GCTCCAGCTC TGACGGAGGC CTCTTCCGCT CCCGGCCCGC CCACTCGCTC CCGCCTGGCG AGGACGGTCG TGTTGAGCCC TATGTGGACT TTGCTGAGTT TTACCGCCTC TGGAGCGTGG ACCATGGCGA GCAGAGCGTG GTGACAGCAC CGTAG

Additionnal Information

TAB1, 3-Tab1, MAP3K7IP1, TAB1, ATGD0004-10 µg, ATGD0004-20 µg, ATGD0004-50 µg, ATGD0004-100 µg, ATGD0004-250 µg, ATGD0004-500 µg, ATGD0004-1 mg, ATGD0004-10, ATGD0004-20, ATGD0004-50, ATGD0004-100, ATGD0004-250, ATGD0004-500, ATGD0004-1

Storage Conditions

Store the plasmid at -20C.

Formulation

Lyophilized

Scientific Category

Immunology

Omim

602615

NCBI Accession Number

NP_006107.1

Species

Human

Preparation

1. Centrifuge at 7000rpm for 1 minute.; ;2. Carefully open the vial and add 100 µL of sterile water to dissolve the DNA.; ; Each tube contains approximately 10 µg of lyophilized plasmid.

RNA Reference

NM_006116.2

DNA Size

1515bp

Vector Description

This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.