Human PRPS1 antibody
PRPS1 is an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. A mutation in PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproductionof purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5) .
Product Specifications
Product Name Alternative
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human PRPS1 (1-318aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT1E11
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
References & Citations
Ishizuka T, et al. (1992) Biochim Biophsy Acta 241130 (2) : 139-48.; ; Kim HJ, et al. (2007) Arn J Hum Gernet 81 (3) :552-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
Scientific Category
Cancer
NCBI Accession Number
NP_002755
Uniprot Accession Number
P60891
WB Description
IF Description
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