What is the catalog number for Human PRPS1 antibody?

The catalog number for Human PRPS1 antibody is ATGA0586-100.

What sizes are available for Human PRPS1 antibody?

Human PRPS1 antibody is available in the following size(s): 100 µL.

Is Human PRPS1 antibody in stock?

Human PRPS1 antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Human PRPS1 antibody

PRPS1 is an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. A mutation in PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproductionof purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5) .

Product Specifications

Product Name Alternative

Ribose-phosphate pyrophosphokinase 1, ARTS, CMTX5, PPRibP, PRSI, DFN2, DFNX1, Ribose-phosphate pyrophosphokinase 1 EC 2.7.6.1, KIAA0967, Phosphoribosyl pyrophosphate synthetase I, PRS I, PRS-I, Ribose phosphate pyrophosphokinase I

Host

Mouse

Antigen Species

Human

Reactivity

Human

Immunogen

Recombinant human PRPS1 (1-318aa) purified from E. coli

Clonality

Monoclonal

Isotype

IgG2a κ

Clone

AT1E11

Conjugation

Unconjugated

Applications

ELISA, WB, ICC/IF

Purification Method

By protein-A affinity chromatography

Concentration

1 mg/mL (determined by BCA assay)

Additionnal Information

PRPS1, ATGA0586-10 µg, ATGA0586-20 µg, ATGA0586-50 µg, ATGA0586-100 µg, ATGA0586-250 µg, ATGA0586-500 µg, ATGA0586-1 mg, ATGA0586-10, ATGA0586-20, ATGA0586-50, ATGA0586-100, ATGA0586-250, ATGA0586-500, ATGA0586-1

References & Citations

Ishizuka T, et al. (1992) Biochim Biophsy Acta 241130 (2) : 139-48.; ; Kim HJ, et al. (2007) Arn J Hum Gernet 81 (3) :552-8.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Applications Notes

The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Scientific Category

Cancer

NCBI Accession Number

NP_002755

Uniprot Accession Number

P60891

WB Description

The cell lysate (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PRPS1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: 293T cell lysate

IF Description

ICC/IF analysis of PRPS1 in HeLa cells. The cell was stained with ATGA0586 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .