What is the catalog number for Human LSM2 antibody?

The catalog number for Human LSM2 antibody is ATGA0581-050.

What sizes are available for Human LSM2 antibody?

Human LSM2 antibody is available in the following size(s): 50 µL.

Is Human LSM2 antibody in stock?

Human LSM2 antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Human LSM2 antibody

LSM2 is a member of the LSm family of RNA-binding proteins. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic complex which is thought to be involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2 complex, which is involved in splicing of nuclear mRNAs. LSM2 associates with multiple snRNP complexes containing the U6 snRNA It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.

Product Specifications

Product Name Alternative

U6 snRNA-associated Sm-like protein LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP core Sm-like protein Sm-x5, C6orf28, YBL026W

Host

Mouse

Antigen Species

Human

Reactivity

Human

Immunogen

Recombinant human LSm2 (1-95aa) purified from E. coli

Clonality

Monoclonal

Isotype

IgG2a κ

Clone

AT1G7

Conjugation

Unconjugated

Applications

ELISA, WB

Purification Method

By protein-G affinity chromatography

Concentration

1 mg/mL (determined by BCA assay)

Additionnal Information

C6orf28, G7b, LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP, snRNP core Sm-like protein Sm-x5, u6 snRNA-associated Sm-like protein LSm2, YBL026W, ATGA0581-10 µg, ATGA0581-20 µg, ATGA0581-50 µg, ATGA0581-100 µg, ATGA0581-250 µg, ATGA0581-500 µg, ATGA0581-1 mg, ATGA0581-010, ATGA0581-020, ATGA0581-050, ATGA0581-100, ATGA0581-250, ATGA0581-500, ATGA0581-01M

References & Citations

Luhtala N, Parker R.Nucleic Acids Res. 2009 Sep 37 (16) :5529-36.; ; Fernandez CF, Pannone BK, Chen X, Fuchs G, Wolin SL .Mol Biol Cell. 2004Jun 15 (6) :2842-52.; ; Achsel T., et al. (1999) EMBO J. 18:5789-5802.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Applications Notes

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_067000

Uniprot Accession Number

Q9Y333

WB Description

The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LSm2 antibody (1:1,000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: MCF7 cell lysate; ; Lane 2.: HeLa cell lysate; ; Lane 3.: 293T cell lysate;