Human TIP30/HTATIP2 antibody
HTATIP2, also known as TIP30, is a member of the short-chain dehydrogenases/reductases (SDR) family. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II) . Defects in This protein are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for HTATIP2 in antitumor therapy.
Product Specifications
Product Name Alternative
Oxidoreductase HTATP2, CC3, TIP30, SDR44u1, Oxidoreductase HTATP2, HTATIP 2, HTATIP-2, CC-3, TIP 30, TIP-30
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human HTATIP2 (1-242aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT5D6
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
References & Citations
Shtivelman E., et al. (1997) Oncogene. 14 (18) : 2167-73. ; ; Xiao H., et al. (1998) Proc Natl Acad Sci u S A. 95 (5) : 2146-2151.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
Scientific Category
Apoptosis
NCBI Accession Number
AAH15358
Uniprot Accession Number
Q9BUP3
WB Description
IF Description
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