Human Otubain-1/OTUB1 antibody
Otubain 1, also known as OTUB1, is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system via its interaction with an ubiquitin protease and E3 ubiquitin ligase. This protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth.
Product Specifications
Product Name Alternative
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human OTUB1 (1-271aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT17E10
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
References & Citations
Balakirev MY., et al. (2003) EMBO Rep. 4 (5) : 5175-5122.; ; Soares L., et al. (2004) Nat Immunol. 5 (1) : 45-54.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_060140
Uniprot Accession Number
Q96FW1
WB Description
IF Description
Frequently Asked Questions
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