Human CAPNS1 antibody
CAPNS1, also known as Calpain small subunit 1, are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Two transcript variants encoding the same protein have been identified for this gene.
Product Specifications
Product Name Alternative
Calpain small subunit 1, Calpain, small subunit 1, 30K, CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human CAPNS1 (84-268aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT1D11
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
References & Citations
Miyake S., et al. (1987) Nucleic Acids Res. 14 (22) : 8805-8817.; ; Ohno S., et al. (1986) Nucleic Acids Res. 14 (13) : 5559.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
Scientific Category
Metabolism
NCBI Accession Number
NP_001740
Uniprot Accession Number
P04632
WB Description
IF Description
ICC/IF analysis of CAPNS1 in HeLa cells. The cell was stained with ATGA0367 (1:100) . The secondary antibody (green) was used Alexa Fluor 488.
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