Human DNAL1 antibody
DNAL1, also known as dynein light chain 1 axonemal, is component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. DNAL1 is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Homozygous mutations in the DNAL1 gene are associated with primary ciliary dyskinesia 16 (CILD16) which is a disorder characterized by abnormalities of motile cilia.
Product Specifications
Product Name Alternative
Dynein light chain 1 axonemal, Dynein light chain 1, axonemal, C14orf168, CILD16
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human DNAL1 (1-190aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
AT29E4
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF, FACS
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
References & Citations
Mazor. M., et al. (2011) Am J Hum Genet 88: 599-607.; ; Horvath. J., et al. (2005) Am J Respir Cell Mol Biol 33: 41-47.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
Scientific Category
Signal Transduction
NCBI Accession Number
NP_113615
Uniprot Accession Number
Q4LDG9
WB Description
FACS Description
IF Description
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