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Human KIR2DL1/KIR2DL3/KIR2DL4 antibody

The kIR family consists of transmembrane glycoproteins of the Ig superfamily expressed on human Nk cells and a subset of human T cells which they are involved in recognition of either MHC class I molecules or unknown ligand on target cells and inhibit cytotoxic activities.

Product Specifications

Product Name Alternative

Killer cell immunoglobulin like receptor two Ig domains and long cytoplasmic tail 4, Killer cell immunoglobulin-like receptor 2DL4, CD158 antigen-like family member D, G9P, Killer cell inhibitory receptor 103AS, KIR-103AS, MHC class I NK cell receptor KIR103AS, CD158D, KIR103AS,103AS, 15.212

Host

Mouse

Antigen Species

Human

Reactivity

Human

Immunogen

Recombinant human KIR2DL4 (44-202aa) purified from E. coli

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

2H6

Conjugation

Unconjugated

Applications

ELISA, WB

Purification Method

By protein-G affinity chromatography

Concentration

1 mg/mL (determined by BCA assay)

Additionnal Information

KIR2DL1, P43626, NP_055033, KIR2DL3, P43628, NP_056952.2, killer cell immunoglobulin like receptor two Ig domains and long cytoplasmic tail 1, Killer cell immunoglobulin-like receptor 2DL1, CD158 antigen-like family member A, Natural killer-associated transcript 1, NKAT-1, p58 natural killer cell receptor clones CL-42/47.11, p58 NK receptor CL-42/47.11, p58.1 MHC class-I-specific NK receptor, CD158a, Killer cell immunoglobulin-like receptor 2DL3, CD158 antigen-like family member B2, KIR-023GB, Killer inhibitory receptor cl 2-3, NKAT2a, NKAT2b, Natural killer-associated transcript 2, NKAT-2, p58 natural killer cell receptor clone CL-6, p58 NK receptor CL-6, p58.2 MHC class-I-specific NK receptor, CD158b2, KIRCL23, KIR2DL4, CD158d, AKR0501-10 µg, AKR0501-20 µg, AKR0501-50 µg, AKR0501-100 µg, AKR0501-250 µg, AKR0501-500 µg, AKR0501-1 mg, AKR0501-010, AKR0501-020, AKR0501-050, AKR0501-100, AKR0501-250, AKR0501-500, AKR0501-01M

References & Citations

Shin JS et al., 1999. Hybridoma 18:521-527.; ; Chwae YJ et al., J Immunology 169:3726-3735.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Applications Notes

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Scientific Category

Immunology

NCBI Accession Number

NP_002246

Uniprot Accession Number

Q99706

WB Description

The recombinant proteins (20ng) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human kIR2D (1:500) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a ECL detection system.; ; Lane 1.: Recombinant human kIR2DL1 protein (23-223aa) ; ; Lane 2.: Recombinant human kIR2DL3 protein (23-223aa) ; ; Lane 3.: Recombinant human kIR2DL4 protein (44-202aa)

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