Recombinant human AG-2/AGR2 protein

AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2) . This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor. Recombinant human AGR2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Anterior gradient protein 2 homolog, AG-2, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog, Protein disulphide isomerase family A member 17, PDIA17

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

21.9 kDa (191aa) confirmed by MALDI-TOF

Additionnal Information

AG2, AGR2, Anterior gradient 2 homolog, AG2, GOB-4, HAG-2, XAG-2, Anterior gradient 2 homolog, AGR 2, Anterior gradient 2 homolog, AGR2, anterior gradient homolog 2 (Xenopus laevis), PDIA17, protein disulfide isomerase family A member 17, Anterior Gradient Protein 2 Homolog, AGR0706-10 µg, AGR0706-20 µg, AGR0706-50 µg, AGR0706-100 µg, AGR0706-250 µg, AGR0706-500 µg, AGR0706-1 mg, AGR0706-10, AGR0706-20, AGR0706-50, AGR0706-100, AGR0706-250, AGR0706-500, AGR0706-1

References & Citations

F.R. Fritzsche. et al., (2007) . Histol Histopathol. 22: 703-708; ; Fletcher GC. et al., (2003) Br J Cancer 88 (4) : 579-85 ; ; Liu D. et al., (2005) Cancer Res. 65 : 3796-805;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM EDTA

Scientific Category

Cancer

NCBI Accession Number

NP_006399.1

Uniprot Accession Number

O95994

Species

Human

AA Sequence

RDTT VKPGAKKDTK DSRPKLPQTL SRGWGDQLIW TQTYEEALYK SKTSNKPLMI IHHLDECPHS QALKKVFAEN KEIQKLAEQF VLLNLVYETT DKHLSPDGQY VPRIMFVDPS LTVRADITGR YSNRLYAYEP ADTALLLDNM KKALKLLKTE L