Recombinant human Adiponecticrp30 protein

Human Adiponectin, also referred to as AdipoQ, Acrp30, apm-1 or GBP28, is a secreted protein expressed exclusively in differentiated adipocyte (adipokine) . Adiponectin contains a modular structure comprising an N-terminal collagenous domain followed by a C-terminal globular domain. Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. Plasma levels of adiponectin are reduced in obese humans, and decreased levels are associated with insulin resistance and hyperinsulinemia.

Product Specifications

Product Name Alternative

ADIPOQ, ACDC, ACRP30, APM1, GBP28, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

25.1 kDa (231aa)

Additionnal Information

Adiponectin, Acrp30, ADI0501-10 µg, ADI0501-20 µg, ADI0501-50 µg, ADI0501-100 µg, ADI0501-250 µg, ADI0501-500 µg, ADI0501-1 mg, ADI0501-10, ADI0501-20, ADI0501-50, ADI0501-100, ADI0501-250, ADI0501-500, ADI0501-1

References & Citations

Maeda K., et al. (1996) Biochem Biophys Res Commun. 221:286-9.; ; Berg AH., et al. (2001) Nat Med. 7:947-53; ; Berg AH., et al. (2002) Trends Endocrinol Metab. 13: 84-89.; ; Yamauchi T et al., (2002) Nat Med. 8:1288-95;

Other References

Jung TW, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. (Biochem Pharmacol. 2006) {https://pubmed.ncbi.nlm.nih.gov/16814256/}; ; Jung TW, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. (Biochem Biophys Res Commun. 2006) {https://pubmed.ncbi.nlm.nih.gov/16554029/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM DTT

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_004788.1

Uniprot Accession Number

Q15848

Species

Human

AA Sequence

MGHDQETTTQ GPGVLLPLPK GACTGWMAGI PGHPGHNGAP GRDGRDGTPG EKGEKGDPGL IGPKGDIGET GVPGAEGPRG FPGIQGRKGE PGEGAYVYRS AFSVGLETYV TIPNMPIRFT KIFYNQQNHY DGSTGKFHCN IPGLYYFAYH ITVYMKDVKV SLFKKDKAML FTYDQYQENN VDQASGSVLL HLEVGDQVWL QVYGEGERNG LYADNDNDST FTGFLLYHDT N