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Human CD45 antibody

CD45 belongs to a family of heavily glycosylated, high molecular weight transmembrane glycoproteins expressed on all cells of haematopoietic origin. Structurally heterogeneous, CD45 consists of a family of eight isoforms ranging from 180, 000 to 220, 000 MW generated by alternative splicing of three exons differentially expressed on subpopulation of lymphocytes. CD45 protein tyrosine phosphatase activity plays a central role in T-cell activation. CD45 plays an important role in signal transduction inhibition or upregulation of various immunological functions

Product Specifications

Product Name Alternative

Protein tyrosine phosphatase, receptor type, C (PTPRC), CD45, B220, CD 45, CD45 antigen, GP180, L CA, LCA, Leukocyte common antigen, LY5, Protein tyrosine phosphatase receptor type C, Protein tyrosine phosphatase receptor type c polypeptide, PTPRC, SCID due to PTPRC deficiency, T200, T200 glycoprotein

Host

Mouse

Antigen Species

Human

Reactivity

Human

Immunogen

Recombinant human CD45 (1029-1249aa) purified from E. coli

Clonality

Monoclonal

Isotype

IgG2a κ

Clone

3G4

Conjugation

Unconjugated

Applications

ELISA, FACS

Purification Method

By protein-G affinity chromatography

Concentration

1 mg/mL (determined by BCA assay)

Additionnal Information

CD45, protein tyrosine phosphatase, receptor type, C (PTPRC), CD45, B220, CD 45, CD45 antigen, GP180, L CA, LCA, Leukocyte common antigen, LY5, Protein tyrosine phosphatase receptor type C, Protein tyrosine phosphatase receptor type c polypeptide, PTPRC, SCID due to PTPRC deficiency, T200, T200 glycoprotein, ACD0802-10 µg, ACD0802-20 µg, ACD0802-50 µg, ACD0802-100 µg, ACD0802-250 µg, ACD0802-500 µg, ACD0802-1 mg, ACD0802-10, ACD0802-20, ACD0802-50, ACD0802-100, ACD0802-250, ACD0802-500, ACD0802-1

References & Citations

Evgueni K , et al., (2005) Immunogenetics 57 (5) :374-383; ; Holmes N., (2006) Immunology 117 (2) :145-155; ; Francois S , et al., (2004) Immunology 113 (4) :441-452; ; Tara S , et al., (2003) Proc Natl Acad Sci U S A 100 (10) :5997-6002

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Applications Notes

The antibody has been tested by ELISA and Flow cytometry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Scientific Category

Immunology

NCBI Accession Number

NM_002838

Uniprot Accession Number

P08575

FACS Description

Flow cytometry analysis of CD45 in Jurkat cells. The cell was stained with ACD0802 at 2-5ug for 1x106cells (red) . A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray) .
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