Endothelin 1 (Human, Highly Pure)

<strong>Endothelin 1 Human</strong>_x000D_ <strong>Catalog number:</strong> B2010216_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> na_x000D_ <strong>Supplied as:</strong> Ready-to-use_x000D_ <strong>Appearance:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> human Endothelin 1, a protein secreted by Endothelial cells with vasoconstrictor properties._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> ET-1_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered on a 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Jagroop IA, Daskalopoulou SS, Mikhailidis DP. Endothelin-1 and human_x000D_ platelets. Curr Vasc Pharmacol. 2005 Oct;3(4):393-9._x000D_ _x000D_ 2: Shihoya W, Nishizawa T, Okuta A, Tani K, Dohmae N, Fujiyoshi Y, Nureki O, Doi_x000D_ T. Activation mechanism of endothelin ET_B receptor by endothelin-1._x000D_ Nature. 2016 Sep 15;537(7620):363-368._x000D_ _x000D_ 3: Raina R, Chauvin A, Vajapey R, Khare A, Krishnappa V. Endothelin-1 as a_x000D_ therapeutic target in autosomal dominant polycystic kidney disease_x000D_ . Clin Nephrol. 2019 Jun;91(6):370-379._x000D_ _x000D_ 4: Olmos G, Martínez-Miguel P, Alcalde-Estevez E, Medrano D, Sosa P, Rodríguez-_x000D_ Mañas L, Naves-Diaz M, Rodríguez-Puyol D, Ruiz-Torres MP, López-Ongil S._x000D_ Hyperphosphatemia induces senescence in human endothelial cells by increasing_x000D_ endo thelin-1 production. Aging Cell. 2017 Dec;16(6):1300-1312._x000D_ _x000D_ 5: Eriksson AK, van Harmelen V, Stenson BM, Aström G, Wåhlén K, Laurencikiene J,_x000D_ Rydén M. Endothelin-1 stimulates human adipocyte lipolysis through the ET A_x000D_ receptor. Int J Obes (Lond). 2009 Jan;33(1):67-74._x000D_ _x000D_ 6: Bousette N, Giaid A. Endo thelin-1 in atherosclerosis and other_x000D_ vasculopathies. Can J Physiol Pharmacol. 2003 Jun;81(6):578-87._x000D_ _x000D_ 7: Jurrissen TJ, Grunewald ZI, Woodford ML, Winn NC, Ball JR, Smith TN, Wheeler_x000D_ AA, Rawlings AL, Staveley-O'Carroll KF, Ji Y, Fay WP, Paradis P, Schiffrin EL,_x000D_ Vieira-Potter VJ, Fadel PJ, Martinez-Lemus LA, Padilla J. Overproduction of_x000D_ endo thelin-1 impairs glucose tolerance but does not promote visceral adipose_x000D_ tissue inflammation or limit metabolic adaptations to exercise. Am J Physiol_x000D_ Endocrinol Metab. 2019 Sep 1;317(3):E548-E558._x000D_ _x000D_ 8: Suzuki Y, Witt L, Mier W, Mikus G, Markert C, Haefeli WE, Burhenne J. Ultra-_x000D_ sensitive and selective quantification of endo thelin-1 in human plasma using_x000D_ ultra-performance liquid chromatography coupled to tandem mass spectrometry. J_x000D_ Pharm Biomed Anal. 2017 Aug 5;142:84-90._x000D_ _x000D_ 9: Higo J, Kasahara K, Wada M, Dasgupta B, Kamiya N, Hayami T, Fukuda I,_x000D_ Fukunishi Y, Nakamura H. Free-energy landscape of molecular interactions between_x000D_ endothelin 1 and human endo thelin type B receptor: fly-casting mechanism._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31608410/">Protein Eng Des Sel.</a> 2019 Dec 31;32(7):297-308._x000D_ _x000D_ <strong>Products Related to Endothelin 1 Human</strong>: <a href="https://moleculardepot.com/product-category/proteins/">Proteins</a>