Royleanone
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1].
Product Specifications
CAS Number
6812-87-9
Product Name Alternative
NSC 122417
UNSPSC
12352211
Target
Akt; mTOR
Type
Natural Products
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/royleanone.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C(C)C)=C(O)C(C2=C1CC[C@@]3([H])C(C)(C)CCC[C@]23C)=O
Molecular Formula
C20H28O3
Molecular Weight
316.43
References & Citations
[1]Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23 (4) :1055-1060.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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