Recombinant Human Epithelial discoidin domain-containing receptor 1 (DDR1), partial , Active Protein

Recombinant Human Epithelial discoidin domain-containing receptor 1 (DDR1), partial , Active Protein is a purified Active Recombinant Protein. Purity: >95% as determined by SDS-PAGE. Host: Mammalian cell. Endotoxin Level: <1.0 EU/ug as determined by LAL method. Species: Human (Homo sapiens) . Target Name: Epithelial discoidin domain-containing receptor 1 (DDR1) . Accession Number: Q08345; DDR1. Expression Region: 21-417aa. Tag Info: C-terminal 10xHis-tagged. Theoretical MW: 46.8kda. Target Synonyms: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix; remodeling of the extracellular matrix; cell migration; differentiation; survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2; MMP7 and MMP9; and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy; for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity) . Promotes smooth muscle cell migration; and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11 Restrictions: For Research Use Only. Not for use in diagnostic procedures.