PLK1/BRD4-IN-2

PLK1/BRD4-IN-2 (compound 15) is a BI-2536 (HY-50698) analog and dual inhibitor that targets both Polo-like kinase 1 (PLK1) and BRD4bromodomain (BRD4-BD1 IC50=28 nM, PLK1 IC50=40 nM) [1].

Product Specifications

CAS Number

[2251709-89-2]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/plk1-brd4-in-2.html

Purity

98.92

Solubility

10 mM in DMSO|DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@H]1N(C2CCCC2)C3=NC(NC4=C(C=C(C=C4)C(N5CCCCCC5)=O)OC)=NC=C3N(C1=O)C

Molecular Formula

C27H36N6O3

Molecular Weight

492.61

References & Citations

[1]Liu S, et al. Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4) /Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61 (17) :7785-7795.https://pubmed.ncbi.nlm.nih.gov/30125504/