PLK1/BRD4-IN-2
PLK1/BRD4-IN-2 (compound 15) is a BI-2536 analog and dual inhibitor that targets both Polo-like kinase 1 (PLK1) and BRD4bromodomain (BRD4-BD1 IC50=28 nM, PLK1 IC50=40 nM).
Product Specifications
CAS Number
2251709-89-2
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plk1-brd4-in-2.html
Purity
98.92
Solubility
10 mM in DMSO|DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@H]1N(C2CCCC2)C3=NC(NC4=C(C=C(C=C4)C(N5CCCCCC5)=O)OC)=NC=C3N(C1=O)C
Molecular Formula
C27H36N6O3
Molecular Weight
492.61
References & Citations
[1]Liu S, et al. Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4) /Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61 (17) :7785-7795.https://pubmed.ncbi.nlm.nih.gov/30125504/
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Frequently Asked Questions
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