ERRα Ligand-Linker Conjugates 1

ERRα Ligand-Linker Conjugates 1 incorporates a ligand for estrogen-related receptor alpha (ERRα), and a PROTAC linker, which recruit E3 ligases MDM2. ERRα Ligand-Linker Conjugates 1 can be used in the synthesis of a series of PROTACs, such as PROTAC ERRalpha Degrader-1 (HY-128838) . PROTAC ERRalpha Degrader-1 is an ERRα degrader[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Target Protein Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/err-alpha-ligand-linker-conjugates-1.html

Purity

98.78

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

NCCNC(/C(C#N)=C/C1=CC(OC)=C(C=C1)OCC2=C(C(F)(F)F)C=C(C(F)(F)F)C=C2)=O.O=C(C(F)(F)F)O

Molecular Formula

C24H20F9N3O5

Molecular Weight

601.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.