A-804598
A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively[1].
Product Specifications
CAS Number
1125758-85-1
UNSPSC
12352005
Hazard Statement
H301
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-804598.html
Purity
98.68
Solubility
DMSO : ≥ 32 mg/mL
Smiles
C[C@H](/N=C(NC1=C2C=CC=NC2=CC=C1)/NC#N)C3=CC=CC=C3
Molecular Formula
C19H17N5
Molecular Weight
315.37
Precautions
H301
References & Citations
[1]Donnelly-Roberts DL et al. [3H]A-804598 ([3H]2-cyano-1-[ (1S) -1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology, 2009 Jan, 56 (1) :223-9.|[2]Yingbo He et al. The role of microglial P2X7: modulation of cell death and cytokine release. Neuroinflammation, 2017 Jul, 14 (1) :135.|[3]Paola Fabbrizio et al. P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia.Cell Neurosci, 2017 Aug, 11:249.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
KN204839BN 1 Kit
Carbonic Anhydrase IX (CA9) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details 
GM-207-15 1 mL
Colloidal Gold Conjugated Monoclonal Antibody to Human IgG4 RJ4, 15nm
Sign In for Pricing
View Details 