A-804598

A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively[1].

Product Specifications

CAS Number

[1125758-85-1]

UNSPSC

12352005

Hazard Statement

H301

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A-804598.html

Purity

98.68

Solubility

DMSO : ≥ 32 mg/mL

Smiles

C[C@H](/N=C(NC1=C2C=CC=NC2=CC=C1)/NC#N)C3=CC=CC=C3

Molecular Formula

C19H17N5

Molecular Weight

315.37

Precautions

H301

References & Citations

[1]Donnelly-Roberts DL et al. [3H]A-804598 ([3H]2-cyano-1-[ (1S) -1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology, 2009 Jan, 56 (1) :223-9.|[2]Yingbo He et al. The role of microglial P2X7: modulation of cell death and cytokine release. Neuroinflammation, 2017 Jul, 14 (1) :135.|[3]Paola Fabbrizio et al. P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia.Cell Neurosci, 2017 Aug, 11:249.