Rilpivirine (hydrochloride)
Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI) . Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM) . Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV[1][2].
Product Specifications
CAS Number
700361-47-3
Product Name Alternative
TMC-278 (hydrochloride) ; TMC278 (hydrochloride) ; TMC 278 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
MMP; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rilpivirine-hydrochloride.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=N2)C=C1.Cl
Molecular Formula
C22H19ClN6
Molecular Weight
402.88
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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