Diflapolin

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) /soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM) [1].

Product Specifications

CAS Number

[724453-98-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epoxide Hydrolase; FLAP

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/diflapolin.html

Purity

99.33

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC3=NC4=CC=CC=C4S3)C=C2C

Molecular Formula

C22H17Cl2N3O2S

Molecular Weight

458.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Garscha U, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7 (1) :9398. Published 2017 Aug 24.