Avadomide (hydrochloride)
Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide. Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities[1][2][3].
Product Specifications
CAS Number
1398053-45-6
Product Name Alternative
CC 122 (hydrochloride)
UNSPSC
12352005
Target
Apoptosis; E1/E2/E3 Enzyme; Molecular Glues; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/avadomide-hydrochloride.html
Smiles
O=C(N1)C(CCC1=O)N2C(C)=NC3=C(C2=O)C(N)=CC=C3.[H]Cl
Molecular Formula
C14H15ClN4O3
Molecular Weight
322.75
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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