Aurothioglucose

Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities[1][2].

Product Specifications

CAS Number

[12192-57-3]

Product Name Alternative

Gold thioglucose

UNSPSC

12352005

Hazard Statement

H317, H334

Target

HIV; NF-κB; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Aurothioglucose.html

Concentration

10mM

Purity

96.10

Solubility

DMSO : 6 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@](O[Au+][SH-]2)([H])C2O[C@H](CO)[C@H]1O

Molecular Formula

C6H11AuO5S

Molecular Weight

392.18

Precautions

H317, H334

References & Citations

[1]Du Y, et al. Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose. J Biol Chem. 2012 Nov 2;287 (45) :38210-9. |[2]Traber KE, et al. Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells. Int Immunol. 1999 Feb;11 (2) :143-50. |[3]Britt RD Jr, et al. The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome. Antioxid Redox Signal. 2014 Jun 10;20 (17) :2681-91.|[4]Naruta E, et al. Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose. Exp Toxicol Pathol. 2001 Oct;53 (5) :393-8.