Aurothioglucose
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities[1][2].
Product Specifications
CAS Number
12192-57-3
Product Name Alternative
Gold thioglucose
UNSPSC
12352005
Hazard Statement
H317, H334
Target
HIV; NF-κB; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Aurothioglucose.html
Concentration
10mM
Purity
96.10
Solubility
DMSO : 6 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@](O[Au+][SH-]2)([H])C2O[C@H](CO)[C@H]1O
Molecular Formula
C6H11AuO5S
Molecular Weight
392.18
Precautions
H317, H334
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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