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Razoxane

Razoxane (ICRF 159), a EDTA derivative, is an orally active antiangiogenic topoisomerase II inhibitor. Razoxane has antineoplastic, antiangiogenic, and antimetastatic activities. Razoxanecan be used for the research of renal cell carcinoma (RCC), lung cancer and melanoma cancer[1][2].

Product Specifications

CAS Number

21416-67-1

Product Name Alternative

ICRF 159

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/razoxane.html

Concentration

10mM

Purity

99.16

Solubility

10 mM in DMSO

Smiles

CC(CN(CC(N1)=O)CC1=O)N(CC(N2)=O)CC2=O

Molecular Formula

C11H16N4O4

Molecular Weight

268.27

Precautions

H315, H319, H335

References & Citations

[1]J P Braybrooke, et al. A phase II study of Razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis. Clin Cancer Res.2000; 6 (12) :4697-704.|[2]F Wingen, et al. Antimetastatic effects of Razoxane in a rat osteosarcoma model. Clin Exp Metastasis.Jan-Mar 1987; 5 (1) :9-16.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Topo II

Available Sizes

Frequently Asked Questions

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