Razoxane
Razoxane (ICRF 159), a EDTA derivative, is an orally active antiangiogenic topoisomerase II inhibitor. Razoxane has antineoplastic, antiangiogenic, and antimetastatic activities. Razoxanecan be used for the research of renal cell carcinoma (RCC), lung cancer and melanoma cancer[1][2].
Product Specifications
CAS Number
21416-67-1
Product Name Alternative
ICRF 159
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/razoxane.html
Concentration
10mM
Purity
99.16
Solubility
10 mM in DMSO
Smiles
CC(CN(CC(N1)=O)CC1=O)N(CC(N2)=O)CC2=O
Molecular Formula
C11H16N4O4
Molecular Weight
268.27
Precautions
H315, H319, H335
References & Citations
[1]J P Braybrooke, et al. A phase II study of Razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis. Clin Cancer Res.2000; 6 (12) :4697-704.|[2]F Wingen, et al. Antimetastatic effects of Razoxane in a rat osteosarcoma model. Clin Exp Metastasis.Jan-Mar 1987; 5 (1) :9-16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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