12-OxoETE
12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence[1][2].
Product Specifications
CAS Number
108437-64-5
Product Name Alternative
12-KETE
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12-OxoETE.html
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\CC(/C=C\C=C\C/C=C\CCCC(O)=O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Naccache PH, Leblanc Y, Rokach J, Patrignani P, Fruteau de Laclos B, Borgeat P. Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: evidence for the involvement of the leukotriene B4 receptor. Biochim Biophys Acta. 1991 Dec 3;1133 (1) :102-6.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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