12-OxoETE

12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence[1][2].

Product Specifications

CAS Number

[108437-64-5]

Product Name Alternative

12-KETE

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/12-OxoETE.html

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\CC(/C=C\C=C\C/C=C\CCCC(O)=O)=O

Molecular Formula

C20H30O3

Molecular Weight

318.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Naccache PH, Leblanc Y, Rokach J, Patrignani P, Fruteau de Laclos B, Borgeat P. Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: evidence for the involvement of the leukotriene B4 receptor. Biochim Biophys Acta. 1991 Dec 3;1133 (1) :102-6.